干细胞领域知识发现平台

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Mengsheng Qiu     美国

University of Louisville

男    博士    【研究领域】分子与基因


3
专利
17
论文
0
项目
5
资讯

H指数

专家简介

Research Focus The long-term goal of our research is to understand the molecular and genetic mechanisms that control the differentiation and regeneration of motor neurons and oligodendrocytes, and develop novel molecular strategies for stimulating the de novo regeneration of motor neurons and oligodendrocytes in the injured spinal cord. We study the molecular and genetic mechanisms that control the specification and differentiation of motor neurons and oligodendrocytes for two reasons. First, they are derived from the same neural progenitor cells in the spinal cord but during different time windows. Thus, a similar set of genes may be involved in the development of these two distinct cell types. Second, motor neurons and oligodendrocytes are functionally important and related as they directly control our body movement, and yet they are particularly susceptible to both genetic and environmental insults, as evidenced by the selective degeneration of motor neurons in Amyotrophic Lateral Sclerosis (ALS), or of oligodendrocytes in multiple sclerosis (MS). In spinal cord injury patients, degeneration of both motor neurons and oligodendrocytes contributes to impaired body movement and function. Studies on the molecular and genetic control of motor neuron and oligodendrocyte development are necessary for developing molecular and cellular strategies for stimulating the de novo regeneration of both cell types in the diseased or injured spinal tissues.

发表论文

论文名称 刊物与发表年
Co‐localization of Nkx6.2 and Nkx2.2 homeodomain proteins in differentiated myelinating oligodendrocytes GLIA
2009
Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS DEVELOPMENT
2014
Dose-dependent regulation of oligodendrocyte specification by β-catenin signaling NEUROSCIENCE BULLETIN
2015
Bone morphogenetic protein signaling and olig1/2 interact to regulate the differentiation and maturation of adult oligodendrocyte precursor cells. STEM CELLS
2007
Selective expression of Nkx-2.2 transcription factor in chicken oligodendrocyte progenitors and implications for the embryonic origin of oligodendrocytes. MOLECULAR AND CELLULAR NEUROSCIENCE
2000
Oligodendrocytes can be generated from the local ventricular and subventricular zones of embryonic chicken midbrain. DEVELOPMENTAL BRAIN RESEARCH
2003
Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling. NEURON
2005
Molecular mapping of the origin of postnatal spinal cord ependymal cells: Evidence that adult ependymal cells are derived from Nkx6.1+ ventral neural progenitor cells THE JOURNAL OF COMPARATIVE NEUROLOGY
2003
Gli2 is required for normal Shh signaling and oligodendrocyte development in the spinal cord MOLECULAR AND CELLULAR NEUROSCIENCE
2003
Migration and differentiation of Nkx-2.2+ oligodendrocyte progenitors in embryonic chicken retina DEVELOPMENTAL BRAIN RESEARCH
2001

研究方向

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