干细胞领域知识发现平台

提升科研信息化水平
支撑研究所科技创新

  融合多源信息    打通数据孤岛
  挖掘知识关联    放大数据价值
  集成知识计算    促进知识发现

免费注册账号
查看全文和研发动态、知识导航以及收藏您喜欢的数据等操作,您需要注册一个免费帐户并登录。

写笔记

您最近的笔记
Screening Method Using Induced Neurons
公开时间: May 19, 2016
申请时间:
申请号:
Patent Application

WO_2016_076435_A1

摘要

The purpose of the present invention is to provide a method for screening preventive or therapeutic anti-tauopathy agents that can prevent the propagation of neurodegeneration caused by tau. This method for screening preventive or therapeutic anti-tauopathy agents contains: a step (1) for bringing a test substance into contact with neurons containing a mutant MAPT gene; a step (2) for measuring the neurons for any one indicator selected from the group consisting of (a) the quantity of tau oligomers in the culture supernatant, (b) the quantity of intracellular tau oligomers, (c) the frequency of depolarization, (d) the concentration of intracellular calcium ions, and (e) the viable cell count; and a step (3) for selecting the test substance as an anti-tauopathy preventive agent or therapeutic agent on the basis of the value of (a), (b), (c), (d), or (e) measured in step (2) in the neurons brought into contact with the test substance in step (1).


申请人


发明人


优先权信息


申请人地址


代理人信息

  •