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Adipose-tissue Derived Stem Cells in Flaps Versus Liposuction
资助者: University of Aarhus
合作者:
监督者:

预计研究完成时间: 2017-08-31
预计完成时间: 2017-08-31

详细标题

  • Adipose-tissue Derived Stem Cells: Characterization of Adipose-tissue Derived Stem Cells in Flaps Versus Liposuction

简略摘要

  • The aim of the study is to evaluate a physiological concentration of adipose tissue-derived stem cells (ASC) in excised fat versus fat harvested by liposuction. Participants will act as their own control as both extraction methods are performed on each participant.

详细摘要

  • Adipose tissue-derived stem cells are of great interest due to their relevance in regenerative medicine and tissue engineering. A reason, being their capacity for multipotent differentiation, tissue repair and immune modulation. To evaluate a physiological concentration level of ASCs in human fat we investigate two extraction methods of fat, excision and liposuction. This is done through a standardised setup with patients acting their own control. The study is carried out in accordance with the guidelines provided by the International Federation for Adipose Therapeutics and Science and International Society for Cellular Therapy.

研究层级

  • Interventional

研究阶段

  • Not Applicable

研究设计

  • Allocation: Non-Randomized
    Intervention Model: Parallel Assignment
    Intervention Model Description:
    Participants will act as their own control. Each participant will receive both excision and liposuction of fat.
    Masking: None (Open Label)
    Primary Purpose: Basic Science

研究条件

  • Mesenchymal Stem Cells

研究干预

  • Procedure: Liposuction Fat harvest by liposuction (Colemans method)

研究手段

  • Active Comparator: Liposuction of fat The intervention examined is the extraction method by liposuction. Intervention: Procedure: Liposuction No Intervention: Excision of fat Control group

出版物

  • Bourin P, Bunnell BA, Casteilla L, Dominici M, Katz AJ, March KL, Redl H, Rubin JP, Yoshimura K, Gimble JM. Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Cytotherapy. 2013 Jun;15(6):641-8. doi: 10.1016/j.jcyt.2013.02.006. Epub 2013 Apr 6.

研究状态

  • Completed

招聘人数

  • 20

招聘准则

  • Inclusion Criteria: Eligible women - over the age of 18 Deemed suitable for abdominoplasty with abdomen pendens, fleur de lis, panniculectomy or belt lipectomy. Able to read and understand Danish Exclusion Criteria: Current smokers - patients not having paused for a minimum of four weeks prior to surgery. Prior or current adjuvant chemo therapy

性别

  • Sexes Eligible for Study: Female

年龄

  • 18 Years and older   (Adult, Older Adult)

志愿者

  • No

联系人

  • Contact information is only displayed when the study is recruiting subjects

国别


NCT编号

  • NCT03105284