干细胞领域知识发现平台

提升科研信息化水平
支撑研究所科技创新

  融合多源信息    打通数据孤岛
  挖掘知识关联    放大数据价值
  集成知识计算    促进知识发现


共找到23条结果
排序:

简介: Artificial insemination is used to improve the genetics of dairy cattle, like this bull.Credit: Leonhard Foeger/ReutersReproductive biologists are developing an unusual way to produce farm animals with desirable traits: injecting surrogate fathers — whose own sperm production has been crippled by gene editing — with sperm-producing stem cells from another male that pass along ‘elite’ genes to offspring. From then on, the surrogate sire's offspring will not be his own, but the donor's.The goal is
简介: Rotator cuff tears are common injuries, and proper healing of the shoulder muscle is often difficult."Chronic tears often result in fat accumulation within the rotator cuff muscles, resulting in negative clinical outcomes, including weakening and atrophy of the muscles," Manuel Schubert, M.D., resident in orthopaedic surgery at Michigan Medicine, said. "It's believed that this process of fat infiltration makes rotator cuff muscle damage one of the most difficult to rehabilitate after injury."Sch
简介: These cloned macaque monkeys are almost genetically identical, and share a mutation that disrupts their sleep cycle. Credit: Institute of Neuroscience, Chinese Academy of SciencesResearchers around the world interested in unravelling the mechanisms of complex human disorders, such as Alzheimer’s disease, could soon have access to cloned monkeys with genomes that have been edited to display these conditions in China.On 24 January, scientists at the Institute of Neuroscience (ION) in Shanghai repo
简介: About 3.4 million Americans, or 1.2 percent of the population, have active epilepsy. Although the majority respond to medication, between 20 and 40 percent of patients with epilepsy continue to have seizures even after trying multiple anti-seizure drugs. Even when the drugs do work, people may develop cognitive and memory problems and depression, likely from the combination of the underlying seizure disorder and the drugs to treat it.A team led by Ashok K. Shetty, PhD, a professor in the Departm
简介: Mice do not naturally develop Alzheimer's disease. Credit: The Jackson LaboratoryDrug companies have spent billions of dollars searching for therapies to reverse or significantly slow Alzheimer’s disease, to no avail. Some researchers argue that the best way to make progress is to create better animal models for research, and several teams are now developing mice that more closely simulate how the disease devastates people’s brains.The US National Institutes of Health (NIH), the UK Dementia Rese
简介: If a new anti-cancer drug shows promise in a Petri dish, often the next step is to test the drug's effect in mice. This system tends to work well with drugs that directly target cancer, but breaks down with immunotherapies. That's because tumors from human cancer samples can only grow in mice with suppressed immune systems. Immunotherapies activate the immune system against cancer. And in a mouse model in which the immune system has been suppressed, there is no immune system to activate against
发布时间