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简介: Glioblastoma is an aggressive form of brain cancer that infiltrates surrounding brain tissue, making it extremely difficult to treat with surgery. Even when chemotherapy and radiation successfully destroy the bulk of a patient's glioblastoma cells, they may not affect the cancer stem cells. This small population of tumor cells have the capacity to grow and multiply indefinitely, and can lead to tumor recurrence.To study these tumors and test new therapies, researchers at University of California
简介: The prostates of older mice contain more luminal progenitor cells -- cells capable of generating new prostate tissue -- than the prostates of younger mice, UCLA researchers have discovered.The observation, published in Cell Reports, helps explain why, as people age, the prostate tends to grow, leading to an increased risk for prostate cancer and other conditions."Understanding what's causing the prostate to grow with age helps us to consider strategies to prevent the expansion of these cells and
简介: Editas Medicine and its partner Allergan have advanced AGN-151587 into a phase I/II trial for patients with Leber congenital amaurosis type 10, a rare and inherited form of blindness.AGN-151587, previously called Edit-101, is the first CRISPR–Cas9 genome-editing medicine that is administered directly to patients. Doctors inject the adeno-associated virus-based candidate subretinally, so that it can cut out a mutation in the CEP290 gene in photoreceptor cells in the eye. Spark Therapeutics and No
简介: Novartis’s breast cancer drug Piqray (alpelisib) was the first new drug application for a new molecular entity approved under the US Food and Drug Administration (FDA) Real-Time Oncology Review (RTOR) pilot program, which aims to speed approvals while ensuring safety. The first targeted small-molecule kinase inhibitor against bladder cancer was approved with an accompanying companion diagnostic. A second drug with marginal efficacy in female sexual arousal disorder, the peptide Vyleesi, was appr
简介: Around 22,000 people will be diagnosed this year in the US with acute myeloid leukemia (AML), the second most common type of leukemia diagnosed in adults and children, and the most aggressive of the leukemias. Less than one third of AML patients survive five years beyond diagnosis.Researchers from Australia's Monash University have discovered a key reason why this disease is so difficult to treat and therefore cure.The study, led by Associate Professor Ross Dickins from the Australian Centre for
简介: This direct-to-consumer stem cell marketplace has come under increasing scrutiny, but relatively little is known about the clinics that deliver these treatments or how the treatments they offer align with the expertise of the practitioners providing them. In a paper published August 1 in the journal Stem Cell Reports, investigators offer a detailed characterization of nearly 170 stem cell businesses across six southwestern states. The study focused on Arizona, California, Colorado, Nevada, New M
简介: Rob Summers was flat on his back at a rehabilitation institute in Kentucky when he realized he could wiggle his big toe. Up, down, up, down. This was new — something he hadn’t been able to do since a hit-and-run driver left him paralysed from the chest down. When that happened four years earlier, doctors had told him that he would never move his lower body again. Now he was part of a pioneering experiment to test the power of electrical stimulation in people with spinal-cord injuries.“Susie, loo
简介: Host: Noah BakerWelcome back to the Nature Podcast. This week, we’ll be hearing about the placental microbiome…Host: Nick HoweAnd learning about advance in AI hardware. I’m Nick Howe.Host: Noah BakerAnd I’m Noah Baker.[Jingle]Interviewer: Nick HoweYou may think of the microbiome as the collection of microorganisms that live in our gut, and that would be right… to a point. But our gut isn’t the only place to host that party of microbes and for the record, the word ‘microbiome’ specifically refers
简介: Antiretroviral drugs stop HIV from replicating in the body.Credit: Siphiwe Sibeko/ReutersHealth authorities have uncovered an alarming surge in resistance to crucial HIV drugs.Surveys by the World Health Organization (WHO) reveal that, in the past 4 years, 12 countries in Africa, Asia and the Americas have surpassed acceptable levels of drug resistance against two drugs that constitute the backbone of HIV treatment: efavirenz and nevirapine.People living with HIV are routinely treated with a coc
简介: For the first time, researchers from the University of Copenhagen have studied and outlined the development of sebaceous glands in the skin. The study provides greater insight into the development and maintenance of the skin and how cancer mutations affect the behaviour of stem cells.Most people are familiar with the sebaceous glands which are responsible for moisturising the skin, and during puberty sometimes more so. But even though the glands are a main component of our skin, scientists know
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