干细胞领域知识发现平台

领域简介

重点针对脑卒中等疾病，致力于建立临床级功能性细胞的制备体系，并着重于利用多种动物模型，包括小动物模型及大动物模型，研究功能细胞移植在安全性、功能整合、再生修复等方面的机制及针对相关疾病的治疗效果。

发表论文

论文名称	刊物与发表年
Where cell fate conversions meet Chinese philosophy	CELL RESEARCH 2014
Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency	CELL STEM CELL 2018
Antagonism between the transcription factors NANOG and OTX2 specifies rostral or caudal cell fate during neural patterning transition	JOURNAL OF BIOLOGICAL CHEMISTRY 2018
Generation of Retinal Organoids with Mature Rods and Cones from Urine-Derived Human Induced Pluripotent Stem Cells	STEM CELLS INTERNATIONAL 2018
Characteristic analyses of a neural differentiation model from iPSC-derived neuron according to morphology, physiology, and global gene expression pattern	SCIENTIFIC REPORTS 2017
PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naive ESCs	NATURE COMMUNICATIONS 2017
A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes	NATURE COMMUNICATIONS 2017
Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells	STEM CELL RESEARCH 2017
Generation of trophoblast-like cells from the amnion in vitro: A novel cellular model for trophoblast development	PLACENTA 2017
Suppressing P16(Ink4a) and P14(ARF) pathways overcomes apoptosis in individualized human embryonic stem cells	FASEB JOURNAL 2017

发表专利

专利名称	专利公开号

相关机构

中国科学院广州生物医药与健康研究院（简称“广州生物院”）是由中国科学院、广东省和广州市人民政府三方共建，从事干细胞与再生医学、化学生物学、感染与免疫、公共健康、科研装备研制等研发的科研机构，于2006年3月获中央机构编制委员会批准正式成立，是中国科学院第一个与地方共建、共管、共有的新型研发机构。广州生物院面向人类健康与“健康中国”战略，聚焦生命健康领域前沿重大科学问题和重要疾病机理，以建成国际一流...