干细胞领域知识发现平台

专家简介

Developmental Biology, Stem Cell Biology We analyze the molecular mechanism of embryonic development by using the most advanced methods such as imaging, optogenetics and transgenic mouse technologies. We evaluate mathematical modeling by using transgenic mice and seek to understand the principles of developmental dynamics.

发表论文

论文名称	刊物与发表年
Use of cell type-specific transcriptome to identify genes specifically involved in Müller glia differentiation during retinal development.	DEVELOPMENTAL NEUROBIOLOGY 2014
Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system	DEVELOPMENT 2006
The Hes gene family: repressors and oscillators that orchestrate embryogenesis	DEVELOPMENT 2007
The identification of transcriptional targets of Ascl1 in oligodendrocyte development	GLIA 2012
Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development	THE INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 2010
Retinal cell fate determination and bHLH factors	SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY 2004
Hes1 and Hes5 are required for differentiation of pituicytes and formation of the neurohypophysis in pituitary development	BRAIN RESEARCH 2015
Oscillations in notch signaling regulate maintenance of neural progenitors.	NEURON 2008
The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain.	JOURNAL OF BIOLOGICAL CHEMISTRY 2003
Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors	THE EMBO JOURNAL 2005

发表专利

专利名称	专利公开号
METHOD FOR INDUCTION OF DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO NERVE CELLS	WO2011007847A1
OPTOGENETIC CONTROL METHOD FOR PROLIFERATION AND DIFFERENTIATION OF STEM CELLS	WO2015041219A1
Optogenetic Control Method For Proliferation And Differentiation Of Stem Cells	WO_2015_041219_A1
Method For Induction Of Differentiation Of Pluripotent Stem Cells Into Nerve Cells	WO_2011_007847_A1

研究方向

机构介绍

The Japanese name of the Institute for Frontier Medical Sciences is Saisei Ikagaku Kenkyujo, which means "Institute for Regenerative Medicine". It is currently the only institute in Japan bearing the name "saisei ikagaku (regenerative medicine)". It has approximately 150 staff members who conduct research on studies related to regenerative medicine, such as basic biology, stem cell biology, and engineering, as well as applied studies on regenerative medicine. Further, the institution provides education and research guidance to approximately 100 graduate students and research students every year. The institution has also been acknowledged as a joint usage/research center for regenerative medicine in order to operate as Japan's core research center for regenerative medicine. Its obligations are continually increasing. We strive in research and education together with the research staff for the development of regenerative medicine. We thank you for your continuing support.

专家资讯

参与项目