干细胞领域知识发现平台

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韩晓平     China

国家自然科学基金委员会

   2018    【研究领域】细胞命运决定与分化及其微环境


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简介: Download transcript PDF This is a transcript of the 11th January 2018 edition of the weekly Nature Podcast. Audio files for the current show and archive episodes can be accessed from the Nature Podcast index page, which also contains details on how to subscribe to the Nature Podcast for FREE, and has troubleshooting top-tips. Send us your feedback to podcast@nature.com. [Jingle] Interviewer: Benjamin Thompson Welcome back to the Nature Podcast. This week we’ll be investigating the shape of    
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简介: To better explore how genomes fold takes disparate fields and a love of math. Jennifer Phillips-Cremins Image: University of Pennsylvania Bioengineering It struck them at the same time: Jennifer Phillips-Cremins of the University of Pennsylvania's bioengineering department and her graduate student Heidi Norton were listening to a Penn colleague, network scientist Danielle Bassett, talk about identifying modules of neural connectivity in functional magnetic resonance imaging data. As Phillips-C    
简介: STING, RIG-I and NLRP3 agonists might increase the effectiveness of immuno-oncology checkpoint inhibitors, while antagonists of these targets offer an anti-inflammatory bonus. Image: Macmillan Publishers Limited Drug developers have launched more than 1,000 combination trials to try to improve patient outcomes with checkpoint inhibitors that harness the body's T cells to kill cancer cells. Until recently, these trials have mostly focused on up-regulating the adaptive immune system — a slow-sta    
简介: Human skeletal stem cells that become bone, cartilage, or stroma cells have been isolated from fetal and adult bones. This is the first time that skeletal stem cells, which had been observed in rodent models, have been identified in humans. The researchers were also able to derive the skeletal stem cells from human induced pluripotent stem cells, opening up new therapeutic possibilities. The discovery appears September 20 in the journal Cell. "Given the tremendous medical burden imposed by dege    
简介: Your body's blood cells are manufactured by hematopoietic stem cells in bone marrow. But just as regular, mature cells can become cancerous, so too can stem cells. When hematopoietic stem cells mutate in specific ways, the result can be damaged stem cells that create a type of pre-leukemic condition known as myelodysplastic syndrome, or MDS. On its own, MDS is a chronic condition that results in symptoms like anemia. In early stages, MDS can usually be managed with supportive care. However, as t    
简介: There are more than 3 million cases of arthritis in the U.S. each year, and osteoarthritis is the most common type. In patients, cartilage -- the slick surface on the ends of bones -- wears away, bone rubs against bone, causing swelling and stiffness. Now Keck School of Medicine of USC scientists in the USC Stem Cell laboratory of Denis Evseenko have collaborated with colleagues to offer new insights on how gene activity drives the development of cartilage. Their findings appear Friday in Natur    
简介: Parkinson's disease is a neurodegenerative disease that affects dopamine signaling neurons in patients' brains. Cell-replacement therapy shows some promise as a treatment for Parkinson's. A recent paper in the journal Molecular & Cellular Proteomics reports a technical advance in selecting cells to use in this therapy. Cell-replacement therapy involves differentiating stem cells into dopamine-signaling, or dopaminergic, neurons and transplanting them into a patient's brain to replace dying neur    
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