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Proliferation and osteo/odontogenic differentiation of stem cells from apical papilla regulated by Zinc fingers and homeoboxes 2: An in vitro study.
Biochemical and Biophysical Research Communications, Issue: 3, Volume: 469, Pages: 599-605. | 2016-01-01
0 Patent citations    1 Scholarly citations     Reference Count: 29
Fang Wan;Lifen Gao;Yating Lu;Hongxin Ma;Hongxing Wang;Xiaohong Liang;Yan Wang;Chunhong Ma

摘要

In the process of tooth root development, stem cells from the apical papilla (SCAPs) can differentiate into odontoblasts and form root dentin, however, molecules regulating SCAPs differentiation have not been elucidated. Zinc fingers and homeoboxes 2 (ZHX2) is a novel transcriptional inhibitor. It is reported to modulate the development of nerve cells, liver cells, B cells, red blood cells, and so on. However, the role of ZHX2 in tooth root development remains unclear. In this study, we explored the potential role of ZHX2 in the process of SCAPs differentiation. The results showed that overexpression of ZHX2 upregulated the expression of osteo/odontogenic related genes and ALP activity, inhibited the proliferation of SCAPs. Consistently, ZHX2 knockdown reduced SCAPs mineralization and promoted SCAPs proliferation. These results indicated that ZHX2 plays a critical role in the proliferation and osteo/odontogenic differentiation of SCAPs.


机构

Shandong University;Department of Immunology, Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection & Immunology, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan, Shandong 250012, PR China; VIP Center, Shandong Provincial Key Laboratory of Oral Biomedicine, School and Hospital of Stomatology, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012, PR China.Shandong University;Department of Immunology, Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection & Immunology, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan, Shandong 250012, PR China.Shandong University;VIP Center, Shandong Provincial Key Laboratory of Oral Biomedicine, School and Hospital of Stomatology, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012, PR China.Shandong University;Department of Immunology, Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection & Immunology, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan, Shandong 250012, PR China.Shandong University;VIP Center, Shandong Provincial Key Laboratory of Oral Biomedicine, School and Hospital of Stomatology, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012, PR China. Electronic address: wangyan1965@sdu.edu.cn.Shandong University;Department of Immunology, Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection & Immunology, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan, Shandong 250012, PR China.Shandong University;Department of Immunology, Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection & Immunology, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan, Shandong 250012, PR China.Shandong University;Department of Immunology, Key Laboratory for Experimental Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection & Immunology, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan, Shandong 250012, PR China. Electronic address: machunhong@sdu.edu.cn.


科学仪器:

微流控芯片   

细胞器官:

liver    blood    B cell    odontoblast    teeth    nerve   

方法技术:

lineage tracing   

疾病:

Tauopathies   

基因:

GAPDH gene    Runx2 gene    OCN gene    Bsp gene    Dspp gene   

实验试剂:

Transcription Factors(D014157)    Homeodomain Proteins(D018398)    ZHX2 protein(C476826)   

免疫治疗:

Biology    Molecular biology    Anatomy    Cell biology    Cell growth    Downregulation and upregulation    Dentin    Odontoblast   

文献类型:

journal article;research support, non-u.s. gov't;

出版商:

Academic Press Inc.

发表时间:

2016-01-01

基金信息

Science and Technique Development Foundation of Shandong province()