干细胞领域知识发现平台

提升科研信息化水平
支撑研究所科技创新

  融合多源信息    打通数据孤岛
  挖掘知识关联    放大数据价值
  集成知识计算    促进知识发现

免费注册账号
查看全文和研发动态、知识导航以及收藏您喜欢的数据等操作,您需要注册一个免费帐户并登录。

写笔记

您最近的笔记
Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin.
Developmental Biology, Issue: 1, Volume: 353, Pages: 1-9. | 2011-01-05
0 Patent citations    35 Scholarly citations     Reference Count: 44
Hugh S Gannon;Lawrence A Donehower;Stephen Lyle;Stephen N Jones

摘要

The p53 transcription factor is activated by various types of cell stress or DNA damage and induces the expression of genes that control cell growth and inhibit tumor formation. Analysis of mice that express mutant forms of p53 suggest that inappropriate p53 activation can alter tissue homeostasis and life span, connecting p53 tumor suppressor functions with accelerated aging. However, other mouse models that display increased levels of wildtype p53 in various tissues fail to corroborate a link between p53 and aging phenotypes, possibly due to the retention of signaling pathways that negatively regulate p53 activity in these models. In this present study, we have generated mice lacking Mdm2 in the epidermis. Deletion of Mdm2, the chief negative regulator of p53, induced an aging phenotype in the skin of mice, including thinning of the epidermis, reduced wound healing, and a progressive loss of fur. These phenotypes arise due to an induction of p53-mediated senescence in epidermal stem cells and a gradual loss of epidermal stem cell function. These results reveal that activation of endogenous p53 by ablation of Mdm2 can induce accelerated aging phenotypes in mice.


机构

University of Massachusetts Medical School;Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA.Baylor College of MedicineUniversity of Massachusetts Medical SchoolUniversity of Massachusetts Medical School


文献类型:

journal article;research support, n.i.h., extramural;

出版商:

Academic Press Inc.

发表时间:

2011-01-05

基金信息

NCI NIH HHS(R56 CA077735)United States