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Stem cells and aberrant signaling of molecular systems in skin aging
Ageing Research Reviews, Issue: , Volume: 19, Pages: 8-21. | 2015-01-01
0 Patent citations    10 Scholarly citations     Reference Count: 240
Yan Peng;Min Xuan;Victor Y L Leung;Biao Cheng

摘要

The skin is the body's largest organ and it is able to self-repair throughout an individual's life. With advanced age, skin is prone to degenerate in response to damage. Although cosmetic surgery has been widely adopted to rejuvinate skin, we are far from a clear understanding of the mechanisms responsible for skin aging. Recently, adult skin-resident stem/progenitor cells, growth arrest, senescence or apoptotic death and dysfunction caused by alterations in key signaling genes, such as Ras/Raf/MEK/ERK, PI3K/Akt-kinases, Wnt, p21 and p53, have been shown to play a vital role in skin regeneration. Simultaneously, enhanced telomere attrition, hormone exhaustion, oxidative stress, genetic events and ultraviolet radiation exposure that result in severe DNA damage, genomic instability and epigenetic mutations also contribute to skin aging. Therefore, cell replacement and targeting of the molecular systems found in skin hold great promise for controlling or even curing skin aging.


机构

University of Hong Kong;Department of Orthopaedics & Traumatology, LKS Faculty of Medicine, The University of Hong Kong, L9-12, Lab block, Hong Kong, SAR, China; Department of Plastic Surgery, Guangzhou General Hospital of Guangzhou command, The Key Laboratory of Trauma Treatment & Tissue Repair of Tropical Area, PLA, GuangDong, 510010, PR China.Southern Medical University;Southern Medical University, Guangzhou, 510010, PR China; Department of Plastic Surgery, Guangzhou General Hospital of Guangzhou command, The Key Laboratory of Trauma Treatment & Tissue Repair of Tropical Area, PLA, GuangDong, 510010, PR China.University of Hong Kong;Department of Orthopaedics & Traumatology, LKS Faculty of Medicine, The University of Hong Kong, L9-12, Lab block, Hong Kong, SAR, China. Electronic address: vicleung@hku.hk.Southern Medical University;Southern Medical University, Guangzhou, 510010, PR China. Electronic address: chengbiaocheng@163.com.


文献类型:

journal article;research support, non-u.s. gov't;

出版商:

Elsevier Ireland Ltd

发表时间:

2015-01-01

基金信息

National Basic Science and Development Program, China()