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Fibromatosis stem cells rather than bone-marrow mesenchymal stem cells recapitulate a murine model of fibromatosis.
Biochemical and Biophysical Research Communications, Issue: 2, Volume: 408, Pages: 269-275. | 2011-05-01
0 Patent citations    3 Scholarly citations     Reference Count: 25
Jung-Pan Wang;Shih-Tien Wang;Yi-Chao Huang;En-Rung Chiang;Chien-Lin Liu;Tain-Hsiung Chen;Shih-Chieh Hung

摘要

Palmar fibromatosis is a benign fibroproliferative tumor of unknown etiology, with a high rate of recurrence after excision. The offending cells of palmar fibromatosis are myofibroblasts and the cellular origin of other myofibroblasts has previously been reported to be the bone marrow. However, further clarification of the relationship between bone marrow precursors and palmar fibromatosis is required. Stem cells (SCs) are known to exist in various tissues, but whether SCs can be isolated from fibromatosis tissue is still unclear. The purpose of this study was to isolate and identify stem cells from human palmar fibromatosis, and to evaluate the differences in the differentiation and fibrogenic capacities of bone marrow stem cells (BMSCs) and fibromatosis-derived stem cells (FSCs). We found that FSCs had better fibrogenic differentiation potential than BMSCs, whereas BMSCs had better adipogenic and chondrogenic differentiation capacities. Treatment with transforming growth factor-β1 increased the expression of α-smooth muscle actin, and types III and I collagen significantly more in FSCs than in BMSCs. An in vivo study further confirmed the results of fibrogenesis and suggested that FSCs can recapitulate the fibromatosis nodule. In summary, their myofibroblastic differentiation both in vivo and in vitro makes FSCs a potential cell source for future applications in murine models of fibromatosis or fibrogenesis.


机构

National Yang-Ming UniversityNational Yang-Ming University;Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. jpwang801@gmail.comNational Yang-Ming UniversityNational Yang-Ming UniversityNational Yang-Ming UniversityNational Yang-Ming UniversityNational Yang-Ming University


文献类型:

journal article;research support, non-u.s. gov't;

出版商:

Academic Press Inc.

发表时间:

2011-05-01

基金信息