干细胞领域知识发现平台

提升科研信息化水平
支撑研究所科技创新

  融合多源信息    打通数据孤岛
  挖掘知识关联    放大数据价值
  集成知识计算    促进知识发现

免费注册账号
查看全文和研发动态、知识导航以及收藏您喜欢的数据等操作,您需要注册一个免费帐户并登录。

写笔记

您最近的笔记
Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors
Human Pathology, Issue: 12, Volume: 41, Pages: 1788-1793. | 2010-01-12
0 Patent citations    12 Scholarly citations     Reference Count: 29
Jane Y Dancer;Stephen P Henry;Jolanta Bondaruk;Sangkyou Lee;Alberto G Ayala;Benoit de Crombrugghe;Bogdan Czerniak

摘要

Recent progress in skeletal molecular biology has led to the clarification of the transcriptional mechanisms of chondroblastic and osteoblastic lineage differentiation. Three master transcription factors—Sox9, Runx2, and Osterix—were shown to play an essential role in determining the skeletal progenitor cells' fate. The present study evaluates the expression of these factors in 4 types of benign bone tumors—chondromyxoid fibroma, chondroblastoma, osteoid osteoma, and osteoblastoma—using immunohistochemistry and tissue microarrays. Osteoid osteoma and osteoblastoma showed strong nuclear expression of Osterix and Runx2. In contrast, only a few chondroblastomas showed positive nuclear expression of Osterix. Strong nuclear expression of Sox9 was detected in all chondroblastomas, whereas nearly half of the osteoblastomas showed focal weak cytoplasmic expression of Sox9.


机构

University of Texas MD Anderson Cancer Center;Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.University of Texas MD Anderson Cancer CenterUniversity of Texas MD Anderson Cancer CenterUniversity of Texas MD Anderson Cancer CenterHouston Methodist HospitalUniversity of Texas MD Anderson Cancer CenterUniversity of Texas MD Anderson Cancer Center


文献类型:

journal article;

出版商:

W.B. Saunders Ltd

发表时间:

2010-01-12

基金信息

NIAMS NIH HHS(R01 AR049072)United States