0 Patent citations 12 Scholarly citations Reference Count: 29
Jane Y Dancer;Stephen P Henry;Jolanta Bondaruk;Sangkyou Lee;Alberto G Ayala;Benoit de Crombrugghe;Bogdan Czerniak
Recent progress in skeletal molecular biology has led to the clarification of the transcriptional mechanisms of chondroblastic and osteoblastic lineage differentiation. Three master transcription factors—Sox9, Runx2, and Osterix—were shown to play an essential role in determining the skeletal progenitor cells' fate. The present study evaluates the expression of these factors in 4 types of benign bone tumors—chondromyxoid fibroma, chondroblastoma, osteoid osteoma, and osteoblastoma—using immunohistochemistry and tissue microarrays. Osteoid osteoma and osteoblastoma showed strong nuclear expression of Osterix and Runx2. In contrast, only a few chondroblastomas showed positive nuclear expression of Osterix. Strong nuclear expression of Sox9 was detected in all chondroblastomas, whereas nearly half of the osteoblastomas showed focal weak cytoplasmic expression of Sox9.
University of Texas MD Anderson Cancer Center;Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.University of Texas MD Anderson Cancer CenterUniversity of Texas MD Anderson Cancer CenterUniversity of Texas MD Anderson Cancer CenterHouston Methodist HospitalUniversity of Texas MD Anderson Cancer CenterUniversity of Texas MD Anderson Cancer Center