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The novel tumour suppressor Madm regulates stem cell competition in the Drosophila testis
Nature Communications, Issue: , Volume: 7, Pages: 10473-. | 2016-01-21
0 Patent citations    5 Scholarly citations     Reference Count: 64
Shree Ram Singh;Ying Liu;Jiangsha Zhao;Xiankun Zeng;Steven X Hou

摘要

Stem cell competition mediates the balance between tissue homeostasis and tumour formation, but how this occurs is unclear. Here, Singh et al. show that the tumour suppressor Mlfl-adaptor molecule regulates the balance between germline stem cell and somatic cyst stem cell growth in the Drosophila testis niche.


机构

National Institutes of Health;The Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA.National Institutes of Health;The Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA.National Institutes of Health;The Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA.National Institutes of Health;The Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA.National Institutes of Health;The Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA.


实验动物:

Drosophila(果蝇)   

科学仪器:

动物监护仪   

细胞器官:

progenitor cell    testis   

基因:

Drosophila Madm gene   

实验试剂:

Drosophila Proteins(D029721)    Tumor Suppressor Proteins(D025521)    Madm protein Drosophila(C000608109)   

免疫治疗:

Biology    Genetics    Somatic cell    Germline   

文献类型:

research support, n.i.h., intramural;journal article;

出版商:

Nature Publishing Group

发表时间:

2016-01-21

基金信息

Intramural NIH HHS(Z99 CA999999)United States