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Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors
The EMBO Journal, Issue: 23, Volume: 24, Pages: 4052-4060. | 2005-12-07
0 Patent citations    43 Scholarly citations     Reference Count: 56
Kyoko Masuda;Hiromi Kubagawa;Tomokatsu Ikawa;Ching-Cheng Chen;Kiyokazu Kakugawa;Masakazu Hattori;Ryoichiro Kageyama;Max D Cooper;Nagahiro Minato;Yoshimoto Katsura;Hiroshi Kawamoto

摘要

T cells are produced in the thymus from progenitors of extrathymic origin. As no specific markers are available, the developmental pathway of progenitors preceding thymic colonization remains unclear. Here we show that progenitors in murine fetal liver and blood, which are capable of giving rise to T cells, NK cells and dendritic cells, but not B cells, can be isolated by their surface expression of paired immunoglobulin-like receptors (PIR). PIR expression is maintained until the earliest intrathymic stage, then downregulated before the onset of CD25 expression. Unlike intrathymic progenitors, generation of prethymic PIR+ progenitors does not require Hes1-mediated Notch signaling. These findings disclose a prethymic stage of T-cell development programmed for immigration of the thymus, which is genetically separable from intrathymic stages.


机构

Kyoto University;Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.;Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology; Yokohama JapanUniversity of Alabama at Birmingham;Department of Pathology, Division of Developmental and Clinical Immunology, University of Alabama; Birmingham AL USAKyoto University;Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology; Yokohama JapanUniversity of Alabama at Birmingham;Department of Pathology, Division of Developmental and Clinical Immunology, University of Alabama; Birmingham AL USAKyoto University;Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology; Yokohama JapanKyoto University;Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University; Kyoto JapanKyoto University;Laboratory of Growth Regulation, Institute for Virus Research, Kyoto University; Kyoto JapanUniversity of Alabama at Birmingham;Department of Pathology, Division of Developmental and Clinical Immunology, University of Alabama; Birmingham AL USAKyoto University;Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University; Kyoto JapanNihon University;Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine; Tokyo JapanKyoto University;Department of Immunology, Institute for Frontier Medical Sciences, Kyoto University; Kyoto Japan


文献类型:

journal article;research support, non-u.s. gov't;

出版商:

Wiley-Blackwell

发表时间:

2005-12-07

基金信息