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The need to identify myeloid dendritic cell progenitors in human blood
Trends in Immunology, Issue: 1, Volume: 31, Pages: 18-23. | 2010-01-01
0 Patent citations    7 Scholarly citations     Reference Count: 67
Alessandra Mortellaro;Siew Cheng Wong;Jan Fric;Paola Ricciardi-Castagnoli

摘要

Dendritic cells (DC) are professional phagocytes possessing a unique ability to sense perturbations in the tissue microenvironment and promote adaptive immune responses, whilst maintaining immunological tolerance. Mouse myeloid DC progenitors with the ability to migrate through the blood and replenish the DC pool have been identified in bone marrow but the ontogeny of human DC is poorly understood. Access to lymphoid tissues for human DC isolation is severely limited and researchers have resorted to the use of in vitro derivation systems in attempts to understand DC development, which may result in misleading conclusions. The identification of a human DC progenitor in blood would greatly enhance the understanding of DC homeostasis and their role in pathogenesis.


机构

Agency for Science, Technology and Research;Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Immunos #04-00, 8A Biomedical Grove, Singapore. alessandra_mortellaro@immunol.a-star.edu.sg Agency for Science, Technology and ResearchAgency for Science, Technology and ResearchAgency for Science, Technology and Research


实验动物:

mouse(小鼠)   

科学仪器:

DNA合成仪   

细胞器官:

bone    blood    dendritic cell   

免疫治疗:

Biology    Immunology    Cell biology    Progenitor cell    Bone marrow    Immune system    Myeloid    Dendritic cell   

文献类型:

journal article;research support, non-u.s. gov't;review;

出版商:

Elsevier Limited

发表时间:

2010-01-01

基金信息