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Cardiomyocyte progenitors in a canine pulmonary vein model of persistent atrial fibrillation
Journal of Cardiology, Issue: 3, Volume: 60, Pages: 242-247. | 2012-01-09
0 Patent citations    4 Scholarly citations     Reference Count: 41
Xian-zhi He;Hai-yu Wang;Qing-hua Zhong;Sheng-xian Fang;Jian-fang Xue

摘要

Summary Background This study aimed to discover the pathogenesis of focal atrial fibrillation (AF) originating from pulmonary veins by observing the histological structure and special cells in the canine pulmonary vein model of persistent atrial fibrillation. Methods The pulmonary veins and the sinus node were obtained from 10 mongrel dogs (5 AF and 5 control group). Light microscopy, transmission electron microscopy, and immunohistochemistry were applied to transverse sections of each pulmonary vein and sinoatrial node. Morphological and distribution analyses were performed manually and automatically. Results Cardiomyocyte progenitor (CMPs) and interstitial cells of Cajal (ICCs) showing typical features of either very immature or developing cells were found in the pulmonary vein sections of all animals subjected to experimental AF but not in the control group. The cells were mainly identified in sections with a thick muscular sleeve. A positive immunostaining of CMPs was also demonstrated; the staining characteristic was similar to that of P cells in the sinoatrial node, suggesting that these cells may function in a pacemaker capacity. Conclusions We demonstrated that pulmonary veins can host cardiac stem cell niches. Continuous rapid pacing can induce the differentiation of CMPs and ICCs, and CMPs may underlie the pacemaker activity of isolated pulmonary veins.


机构

Central South UniversityCentral South UniversityCentral South UniversityDepartment of Cardiology, Longgang District Central Hospital of Shenzhen, Guangdong, China.Central South University


科学仪器:

DNA测序仪/基因测序仪   

免疫治疗:

Anatomy    Progenitor cell    Medicine    Internal medicine    Cardiology   

文献类型:

journal article;

出版商:

Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai)

发表时间:

2012-01-09

基金信息