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Jelly belly: A Drosophila LDL Receptor Repeat-Containing Signal Required for Mesoderm Migration and Differentiation
Cell, Issue: 3, Volume: 107, Pages: 387-398. | 2001-11-02
0 Patent citations    49 Scholarly citations     Reference Count: 42
Joseph Weiss;Kaye Suyama;Hsiu-Hsiang Lee;Matthew P Scott

摘要

Abstract Inductive interactions subdivide the Drosophila mesoderm into visceral, somatic, and heart muscle precursors. The muscle precursors form organs by executing tissue-specific migrations and cell fusions. We identified a novel gene, jelly belly (jeb) , which is required for visceral mesoderm development. jeb encodes a secreted protein that contains an LDL receptor repeat. In jeb mutants, visceral mesoderm precursors form, but they fail to migrate or differentiate normally; no visceral muscles develop. Jeb protein is produced in somatic muscle precursors and taken up by visceral muscle precursors. jeb reveals a signaling process in which somatic muscle precursors support the proper migration and differentiation of visceral muscle cells. Later in embryogenesis, jeb is transcribed in neurons and Jeb protein is found in axons.


机构

Stanford University;Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center B300, 279 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305, USA. weissjo@ohsu.eduStanford UniversityIcahn School of Medicine at Mount SinaiStanford University


文献类型:

journal article;research support, u.s. gov't, p.h.s.;research support, non-u.s. gov't;

出版商:

Cell Press

发表时间:

2001-11-02

基金信息

NHLBI NIH HHS(KO8 HL03627-05)United States