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Vectors And Methods For Targeted Integration In Loci Comprising Constitutively Expressed Genes

公开时间: May 19, 2016
申请时间:
申请号:

Patent Application

WO_2016_074016_A1

摘要

The invention relates to a vector comprising: a 5' nucleic acid that is homologous to a genomic sequence 5' of a stop codon of a constitutively expressed gene; an exogenous nucleic acid; a 3' nucleic acid that is homologous to a genomic sequence 3' of the stop codon of the constitutively expressed gene; a translation interruption-reinitiation signal operably linked to the 5' nucleic acid and the exogenous nucleic acid, wherein the translation interruption-reinitiation signal is capable of replacing the stop codon of the constitutively expressed gene.

申请人

发明人

优先权信息

申请人地址

代理人信息

IPC分类号

C12N15/85 C12N5/10

CPC分类号

A01K2217/072 A01K2217/203 A01K2267/0393 C12N15/85 C12N15/907 C12N2800/24 C12N2830/002 C12N2840/107 C12N2840/203 C12N5/10

USPC分类号

实验动物：

rat(大鼠) mouse(小鼠) mice

科学仪器：

Microbial Detection Instruments(微生物检测仪器)

细胞器官：

Schwann cell cord blood

方法技术：

cloning DNA sequencing image analysis ionization time-of-flight mass spectrometry

基因：

Ptch2 gene

免疫治疗：

Morphogenesis Monocyte

实验方案：

Microplate Protocols(显微术方案)

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摘要

申请人

发明人