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Method of mobilizing hematopoietic stem cells
公开时间: 1997-04-24
申请时间: 1996-10-23
申请号: ZA19960008896
发明专利

ZA9608896A

摘要


主权项

22| WHAT IS CLAIMED IS:| 1. Use of a protein derived from a mammalian chemokine selected from the group consisting of (a) groa SEQ ID NO:2, (b) groB SEQ ID NO: 3, (c) groy SEQ ID NO:4 and (d) KC SEQ ID NO:l, in the preparation of a medicament useful for mobilizing hematopoietic stem cells.| 2. Use according to claim 1 wherein said chemokine is selected from the group consisting of:| (a) mature grrojS;| (b) amino acids 5 to 73 of SEQ ID NO: 3;| (c) a multimeric chemokine protein which comprises an association of two or more of (a) or (b); and| (d) a multimeric chemokine protein which comprises an association of (a) or (b) with a second chemokine.| 3. Use according to claim 1 wherein said chemokine is selected from the group consisting of:| (a) mature groa;| (b) amino acids 5 to 73 of SEQ ID NO: 2;| (c) a multimeric chemokine protein which comprises an association of two or more of (a) or (b); and| (d) a multimeric chemokine protein which comprises an association of (a) or (b) with a second chemokine.| 4. Use according to claim 1 wherein said chemokine is selected from the group consisting of:| (a) mature groy,| (b) amino acids 5 to 73 of SEQ ID NO: 4;| 23| (c) a multimeric chemokine protein which comprises an association of two or more of (a) or (b);| and| (d) a multimeric chemokine protein which comprises an association of (a) or (b) with a second chemokine.| 5. Use according to claim 1 wherein said chemokine is selected from the group consisting of:| (a) mature KC;| (b) amino acids 5 to 72 of SEQ ID NO: 1;| (c) a multimeric chemokine protein which comprises an association of two or more of (a) or (b);| and| (d) a multimeric chemokine protein which comprises an association of (a) or (b) with a second chemokine.| 6. Use according to claims 1-5 wherein said chemokine comprises between about 0.01 ng to about 1 g of said medicament.| 7. Use according to claims 1-5, wherein said medicament is co-administered with a growth factor or other hematopoietic regulatory biomolecule.| 8. Use according to claim 7 wherein said growth factor is selected from the group consisting of GM-CSF, G-CSF, stem cell factor, and Flt-3 ligand.| 9. Use according to claim 7 where said biomolecule is (S)-5-oxo-L-prolyl-a-glutamyl-L-a-aspartyl-N8- (5-amino-l-carboxypentyl) -8-oxo-N7- [N-{N- (5-oxo-L-prolyl)-L-a-glutamuyl}-L-a-aspartyl]-L-threo-2,7,8-triaminooctanoyl-lysine [ (pGlu-Glu-Asp)2-Sub-(Lys)2] •| 24| 10. Use according to claim 1 wherein the medicament is used in the treatment of a patient receiving peripheral blood hematopoietic stem cell transplantation.| 11. Use according to claim 10 wherein the patient has received a dose of a selected chemotherapeutic agent prior to treatment with the medicament; the hematopoietic stem cells from the peripheral blood of the patient treated are harvested; a chemotherapeutic agent is administered; and the patient is reinfused with the harvested cells.| chemotherapeutic agent is selected from the group consisting of cyclophosphamide, cisplatinum, ARA-C, 5-fluorouracil, etopside, epirubicin, carboplatin,| busulphan, mitoxantrone and carmustine.| 13. Use according to claim 1, wherein the protein is substantially as herein described with reference to the accompanying examples.| 12. Use according to claim 11 wherein said| Attorney/Agent for the Applicant rs day of (Sc3lobsvi9S!(o|


申请人


发明人


优先权信息

  • US19950547262

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