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METHOD FOR INDUCTION OF DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO NERVE CELLS
公开时间: 2011-01-20
申请时间: 2010-07-15
申请号: WO2010JP62014
发明专利

WO2011007847A1

摘要

Disclosed is a method for producing nerve cells from pluripotent stem cells, which is characterized by inhibiting the expression or function of Hes1 in the pluripotent stem cell. The method comprises the steps of: (a) bringing the pluripotent stem cells into contact with a substance capable of inhibiting the expression or function of Hes1; and (b) culturing the cells under conditions where the differentiation of the cells into nerve cells can be induced. Also disclosed are: a differentiation inducer comprising a substance capable of inhibiting the expression or function of Hes1; a nerve cell derived from a pluripotent stem cell, which is produced by the method; and a therapeutic agent for nerve diseases, which comprises the nerve cell.


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