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Abstract

Use of (i) an anti-CD3 antibody, (ii) an anti-CD56 antibody, (iii) an anti-CD14 antibody, (iv) an anti-CD38 antibody, (v) an anti-CD45 antibody, (vi) an anti-CD90 antibody, (vii) an anti- CD135 antibody, (viii) an anti-CD10 antibody, (ix) an anti-CD11c antibody, (x) an anti-CD19 antibody, (xi) an anti-CD34 antibody, (xii) an anti-CD45RA antibody, (xiii) an anti-CD7 antibody, (xiv) an anti-CD71 antibody, (xv) an anti-CD41/CD61 complex antibody or an anti- CD41 antibody and/or an anti-CD61 antibody (xvi) an anti-CD33 antibody and/or an anti- CD66b antibody, for identifying hematopoietic cell subtypes in an isolated sample, determining the relative frequency of hematopoietic cell subtypes in an isolated sample and/or quantifying the number of cells within hematopoietic cell subtypes in an isolated sample, wherein each of (i) to (xvi) is labelled with a different fluorochrome, wherein when (xvi) is an anti-CD33 antibody and an anti-CD66b antibody, the anti-CD33 antibody and anti-CD66b are labelled with the same fluorochrome, and wherein when (xv) is an anti-CD41 antibody and an anti-CD61 antibody, the anti-CD4 antibody and the anti-CD61 antibody are labelled with the same fluorochrome.


Abstract

Methods are disclosed for forming bone and/or cartilage in an avian subject. The methods include administering to the avian subject a therapeutically effective amount of a composition comprising avian mesenchymal stem cells and a hydrogel that supports the differentiation of the avian mesenchymal stem cells into cells of an osteogenic and/or condrogenic lineage. In some embodiments, methods are disclosed for repairing a bone defect and preventing infection, such as that associated bone fracture, in an avian subject. The methods include administering locally to the bone defect a composition comprising a therapeutically effective amount of avian mesenchymal stem cells and a hydrogel, such as a methacrylated gelatin hydrogel.


Abstract

Provided is a cocktail of factors for converting/reprogramming non-naïve pluripotent stem cells into TGFβ signaling-independent (TSI) naïve induced pluripotent stem cells (iPSCs). Also provided are methods for reprograming a non-naïve PSC into a TSI naïve iPSC by contacting the cell to be reprogrammed with effective amounts of compounds for a sufficient period of time to reprogram the cell into a TSI naïve iPSC.


Abstract

Certain embodiments are directed to compositions and methods for non-cytotoxic hematopoietic stem cell transplantation.

公开时间: 2015-10-22
发明人:Alenfall Jan, Dunér Pontus, Nilsson Anna Hultgårdh, Paus Ralf
知识棱镜:

Abstract

The present invention provides a composition for inhibiting hair production in a mammal comprising an active polypeptide component and a pharmaceutically acceptable and/or cosmetically acceptable excipient, carrier or diluent. The invention further provides methods of inhibiting hair production in a mammal, e.g. human.


Abstract

The present invention relates to compositions and methods utilizing hair follicle derived Non-Bulbar Dermal Sheath cells for use in the treatment of dental-related conditions, including the treatment of gingivitis. Briefly stated, the present invention provides compositions and methods for treating or preventing a wide variety of conditions associated with the oral cavity, including for example, periodontal disease and a variety of diseases or injuries associated with the gingiva utilizing hair follicle derived Non-Bulbar Dermal Sheath ("NDBS") cells. Within one aspect of the invention methods are provided for isolating NBDS cells, comprising the steps of: preparing vital hair and cleaving the hair.

公开时间: 2015-06-11
发明人:Wucherpfennig Kai W, Dranoff Glenn, Hodi F Stephen, Franz Bettina, May Kenneth F Jr, Harvey Christopher
知识棱镜:

Abstract

The present disclosure provides, in part, compositions comprising peptides immunospecifically binds to MHC class I polypeptide-related sequence A (MICA).


Abstract

A method and system of treating a disease for a patient, comprising assigning class data related to a class of patients that have characteristics similar to a specific patient and/or accessing patent data related to the specific patient; and optimizing a treatment plan, the optimizing being determined utilizing properties of a radiopharmaceutical used to treat the patient and the class data and/or the patient data.


Abstract

Embodiments of the present invention are directed to methods of altering the surface of a substrate to improve cell adhesion, proliferation and/or differentiation on the surface of the substrate. Substrates within the scope of the present invention include implant surfaces where cell adhesion is desired and/or cellular growth and/or cellular differentiation on the substrate itself or at the location of the implant within the body.

公开时间: 2011-03-17
发明人:Kawase Yoshiaki, Ladage Dennis, Hajjar Roger Joseph
知识棱镜:

Abstract

Compositions, biologies and methods for injection into or near the pericardial space are provided. In some embodiments, a sustained release vehicle is used to deliver an active agent in a controlled manner to treat the heart of a subject. The sustained release vehicle may be, for example, a hydrogel particle. In certain embodiments, a vehicle may be used to deliver an active agent comprising a biological entity such as a virus or cell to the pericardial space. In certain embodiments, compositions and methods are provided for inhibiting formation of tissue adhesions within the pericardial space.

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