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Abstract

Methods are disclosed for forming bone and/or cartilage in an avian subject. The methods include administering to the avian subject a therapeutically effective amount of a composition comprising avian mesenchymal stem cells and a hydrogel that supports the differentiation of the avian mesenchymal stem cells into cells of an osteogenic and/or condrogenic lineage. In some embodiments, methods are disclosed for repairing a bone defect and preventing infection, such as that associated bone fracture, in an avian subject. The methods include administering locally to the bone defect a composition comprising a therapeutically effective amount of avian mesenchymal stem cells and a hydrogel, such as a methacrylated gelatin hydrogel.

公开时间: 2016-01-28
发明人:Brogdon Jennifer, Ebersbach Hilmar, Gill Saar, Glass David, Huber Thomas, Jascur Julia, Kenderian Saad, Mannick Joan, Milone Michael C, Murphy Leon, Richardson Celeste, Singh Reshma, Song Huijuan, Wu Qilong, Zhang Jiquan
知识棱镜:

Abstract

The disclosure provides compositions and methods for treating diseases associated with expression of CD33. The disclosure also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The disclosure also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.

公开时间: 2004-07-01
发明人:Heerding Dirk A, Price Alan T, Safonov Igor
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Abstract

Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected benzimidazole derivative.

公开时间: 2009-08-13
发明人:ARAKI KIMI JP, YAMAMURA KEN-ICHI JP
知识棱镜:

Abstract

A trap vector containing a loxP sequence composed of inverted repeat sequence 1, a spacer sequence and inverted repeat sequence 2 in this order, the loxP sequence being a mutant loxP wherein a part of the inverted repeat sequence 1 or 2 is mutated.

公开时间: 2008-06-12
发明人:NISHIMURA EMI K., FISHER DAVID E.
知识棱镜:

Abstract

The invention relates to methods and compositions useful for altering and assessing melanocyte stem cell self-maintenance. Loss of such self-maintenance results in loss of melanocyte stem cells and loss of natural pigmentation of hair (e.g., graying hair). Methods for identifying candidate agents to inhibit melanocyte stem cell loss and to treat subjects with loss of natural hair pigment are also provided.

公开时间: 2007-05-03
发明人:GROSS JANE A US, HAMMOND ANGELA K US, DILLON STACEY R US, FOSTER DONALD C US, JOHNSTON JANET V US, HOLLY RICHARD D US, PRESNELL SCOTT R US, NELSON ANDREW J US, NOVAK JULIA E US, SPRECHER CINDY A US
知识棱镜:

Abstract

Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.

公开时间: 2013-07-30
发明人:PARK SO RA KR, CHOI BYUNG HYUNE KR, KIM NA KYEONG KR
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Abstract

PURPOSE: A composition for induction of movement of mesenchyme stem cell, and its inducing method are provided to make acquisition of the mesenchyme stem cell, thereby facilitating the picking. CONSTITUTION: A composition for induction of movement of mesenchyme stem cell comprises a colony stimulating factor (CSF) as an active ingredient. The colony stimulating factor comprises: GM-CSF (granulocyte macrophage-colony stimulating growth factor) and one or more than one selected from a group comprising G-CSF (granulocyte-colony stimulating growth factor). The mesenchyme stem cell exists in the bone marrow. The induction of movement method to the peripheral blood of the mesenchyme stem cell comprises the following steps. A step of multiplying the mesenchyme stem cell it processes the colony stimulating factor. The above-mentioned proliferated mesenchyme stem cell the step of moving to peripheral blood is included.


Abstract

Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem cells in an undifferentiated state. It has now been found that if high levels of fibroblast growth factor are used in a medium with gamma amino butyric acid, pipecholic acid, lithium and lipids, the stem cells will remain undifferentiated indefinitely through multiple passages, even without feeder cells or conditioned medium. A humanized matrix of human proteins can be used as a basement matrix to culture the cells. New lines of human embryonic stem cells made using these culture conditions, the medium and the matrix, will never have been exposed to animal cells, animal products, feeder cells or conditioned medium.


Abstract

We describe a method for the isolation of normal prostate stem cells which express CD133 antigen; stem cells isolated by the method and their use.


Abstract

本发明公开辅酶NADH在组织细胞化学和辐射损伤防治中的应用。该酶能选择性早期预防正常组织细胞免受化学和辐射损伤以及细胞毒药物的DNA损伤和凋亡产生。NADH能阻断凋亡分子Caspase-3和Caspase-8表达,阻止细胞色素C从线粒体释放到胞浆,抑制凋亡时线粒体膜电位下降和游离钙离子升高,降低ROS释放。NADH能促进正常细胞增殖生长,外源性补充NADH能修复损伤细胞,并能通过上调Bcl-2基因表达和下调P53基因表达抑制凋亡。NADH可作为肿瘤放化疗保护剂和防治化学和核武器损伤的有效生物战剂。

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