干细胞领域知识发现平台

[2020-10-18] Shinya Yamanaka：基于多能干细胞的细胞治疗，未来可期

简介: 细胞疗法是一种将活细胞注射、移植或植入患者体内，旨在修复疾病起源和发展的机制的治疗方法。细胞治疗利用干细胞、祖细胞、原代细胞或干细胞衍生物来替代或修复受损的器官或组织，这些细胞可以通过静脉注射，直接转移到受累区域，或者从患者自身组织中招募来诱导自我修复。而多能干细胞（PSC）的自我更新和分化潜能使其成为细胞疗法最有利的细胞来源【1】，目前应用于临床研究的人类PSC（hPSC）主要有两类——胚胎干细胞（ESC）和诱导多能干细胞（iPSC）。1998年，James Thomson团队首次报道了人类ESC（hESC）【2】，此后其逐渐被探索用于各种疾病和损伤的细胞治疗，如脊髓损伤、年龄相关黄斑变性和1型糖尿病。然而hESC的临床应用一直存在着两个主要问题——伦理问题和免疫排斥，因此，2007年人类iPSC（hiPSC）应运而生【3】。从此以后，科学家们一直试图将hiPSC应用于患者，其中一些已经在进行临床试验（图1）。图1使用PSC进行细胞治疗的临床试验随着研究的深入，现如今对实现PSC细胞治疗的期望达到了有史以来的顶峰，但是，其临床转化仍然遇到了许多问题。2020年10月1日，来自日本京都

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[2019-03-15] 科学家鉴定出肝脏中Sox9+双向祖细胞

简介:    2月14日，中国科学院生物化学与细胞生物学研究所周斌研究组在国际学术期刊Stem Cell Reports上发表了题为Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration 的最新研究成果。该项工作基于更为精准的遗传谱系示踪系统，利用Sox9-CreER和HNF4a-DreER双同源重组技术特异性标记了Sox9+的肝细胞而非Sox9+的胆管细胞。结合基于双同源重组酶的新型Confetti报告基因小鼠，进行克隆分析实验阐明：单个Sox9+的肝细胞在肝损伤后可以同时产生肝细胞和胆管细胞。该项研究首次证明了Sox9+肝细胞在肝损伤后可作为双向祖细胞同时产生肝细胞和胆管细胞参与肝脏修复和再生。在肝脏稳态情况下，肝细胞更新非常缓慢，而在损伤过程中，肝脏再生能力非常旺盛。肝脏中含有肝脏祖细胞，参与维持肝脏的体内平衡。在损害肝细胞增殖的慢性肝损伤情况下，胆管细胞可以充当干细胞并产生肝细胞参与肝修复再生。此外，肝细胞在某些损伤条件下也可以经历由肝细胞到胆管细胞的转

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[2019-03-11] 中科院院长：基因编辑不能因噎废食叫停一切不妥

简介: “基因编辑婴儿事件发生后，国际学术界非常关注，美国科学院、英国皇家学会等单位共同发起了关于该事件的大讨论，并邀请了中国科学院参加，国际科学界对一些问题形成了共识。”9日，全国人大代表、中国科学院院长、党组书记白春礼说，共识包括：就目前而言，在技术不成熟、相应的社会伦理问题未得到充分讨论解决之前，我们应当禁止对于人生殖系基因编辑的临床试验和应用；而对于基础性研究则可以允许科学家尝试探索，否则会影响科技创新的步伐。白春礼认为，生物技术立法应当顺应新兴生产力发展的需求，为生物技术发展保驾护航。“法律的制定要在科学规范、避免误用滥用和鼓励科研探索之间掌握好‘度’，不能‘因噎废食’。”严禁反人类的误用、滥用“除了基因编辑技术，还有辅助生殖技术、克隆技术、器官再造技术等，都对传统的生命伦理观提出了挑战。”白春礼说，无节制地应用，可能会引发生命随机选择、代际混乱、器官商业化、基因歧视等问题。白春礼将此类利用定义为：不法研究对生物技术的反人类利用，任其发展将有可能侵害至高无上的人性尊严和生命价值。“不允许以生殖为目的对人类胚胎或者受精卵进行基因编辑是业界共识，但仅仅靠伦理道德、自我约束会出现有意逃避监

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[2019-01-24] Japan’s approval of stem-cell treatment for spinal-cord injury concerns scientists

简介: A stem cell treatment for spinal cord injuries will soon be available in Japan. Credit: Steven Needell/SPLJapan has approved a stem-cell treatment for spinal-cord injuries. The event marks the first such therapy for this kind of injury to receive government approval for sale to patients.“This is an unprecedented revolution of science and medicine, which will open a new era of healthcare,” says oncologist Masanori Fukushima, head of the Translational Research Informatics Center, a Japanese govern

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[2018-07-11] Two Excellent Young Researchers Honoured in Heidelberg

简介: Marieke Essers and Theodore Alexandrov have received Chica and Heinz Schaller Award for basic biomedical researchPhoto: Rothe Chica und Heinz Schaller Award for basic biomedical research: Dr Marieke Essers (second from right) and Dr Theodore Alexandrov (centre) receiving the award. The award was handed over by the foundation’s Chairperson, Prof. Dr Rohini Kuner (second from left), Board member Prof. Dr Karoly Nikolich (left) und Prof. Dr Hans-Georg Kräusslich (right), Chairperson of the Scientif

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[2018-07-04] DKFZ trainee wins Helmholtz Apprentice Award with a stem cell culture

简介: A great success for one of DKFZ’s young staff members: 22-year old Franziska Pilz came second in the Helmholtz Apprentice Award. The jury commended her for her “significant contribution to the further development of stem cell research and for her independent, proactive and responsible work”. Franziska Pilz who is currently training to be a biology laboratory assistant, worked on a project on the stem cell niche. She accepted her award on April 7.“I’m really delighted and also a little bit proud”

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[2018-06-07] European Health Catapult winners named at EIT Health Summit

简介: 06 December 2017The European Health Catapult Competition reached its climax on 5 December at the EIT Health Summit in London, where a jury of experts announced the winning start-ups in the Medtech, Biotech and Digital Health categories.MedtechFollowing a year of training and competition, the top 21 of the original 42 start-ups that were accepted for the prograrmme competed for cash awards and the attention of potential investors at the EIT Health Summit in the European Health Catapult finals. Th

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[2018-05-28] BioRN Lounge welcomed Prof. Steffen Rupp from Fraunhofer IGB

简介: Heidelberg, 17.05.2018BioRN Lounge: Prof. Steffen Rupp from Fraunhofer IGB talked about: ”Innate Immunity in 3D-Infection models: From simple Screening Systems to complex Immune Cell supplemented Skin Models”Once again, the BioRN Lounge was the occasion for the life science companies as well for scientists from our research institutes, to meet and chat about latest news and achievements. The BioRN Lounge is the prime monthly networking event for BioRN members. It is the occasion for exchange, me

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[2018-04-04] Anemia: When cells fail to produce enough protein factories: Researchers gain new insights into blood cell formation

简介: Every day, stem cells in our bone marrow produce billions of new red blood cells. Any disruption in this process can result in serious disease. Researchers from Charité -- Universitätsmedizin Berlin and Harvard Medical School have succeeded in furthering our understanding of how blood cells are formed. Their insights into the molecular foundations of this process may help break new ground in the treatment of certain types of anemia. The results of this study have been published in Cell.Thanks to

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[2018-03-13] BioMed X and Roche announce research collaboration in the field of immunology

简介: BioMed X announced today the initiation of a new research collaboration with F. Hoffmann-La Roche Ltd in the field of immunology. Within the framework of the agreement, BioMed X will launch a global call for applications to establish a new biomedical research group in Heidelberg. The main objective of the new group will be to develop novel approaches for the treatment of several immune-mediated diseases.Myeloid cells are capable of dynamically exerting diverse functions in the immune system, as

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