干细胞领域知识发现平台

[2020-07-15] Attorney General files lawsuit against Nebraska company over stem cell therapy claims

简介: Iowa’s attorney general filed suit today in Polk County District Court against a Nebraska-based stem cell therapy center.Attorney General Tom Miller accuses Regenerative Medicine and Anti-Aging Institutes of Omaha of making deceptive, misleading claims that targeted older Iowans.  “They made incredibly strong claims about dealing with pain, back pain, knees, hips, arthritis, but they went beyond that,” Miller says. “They made claims that they could reverse COPD to some extent, and even in t

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[2020-07-13] Cancer Stem Cell Therapeutics Market Checkout the Unexpected Future 2027 | Key Players – Merck KGA, LONZA Group AG, Novartis, Osiris Therapeutics, Pfizer

简介: Jul 09, 2020 (Market Insight Reports) -- The report studies the current market scenario and growth opportunities existing in the market during the forecast period. The report also includes reliable information about regional and global consumption to help readers understand the market dynamics. The report gives a detailed assessment of the leading players with key information like definition, applications, drivers, market players, major segments, product offerings and specifications, company pro

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[2020-07-12] Lemington family need £20,000 every six months to take ill son to Panama for stem cell treatment

简介: A Newcastle family must raise £20,000 every six months to take their seriously ill son to Panama for lifesaving treatment.Starved of oxygen at birth, Sean Gallagher has severe cerebral palsy and is not expected to survive long into his teens.His parents Sonia and Sean, from Lemington, started hunting for treatment in a bid to give him the best possible quality of life in whatever time he has left.Sean has severe difficulties, including seizures, scoliosis and being registered blind, partially de

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[2020-07-07] VetStem Biopharma Reaches New Stem Cell Treatment Milestone

简介: Leading regenerative medicine company, VetStem Biopharma, has processed nearly 14,000 patient samples resulting in over 30,000 stem cell treatments.POWAY, CALIFORNIA, USA, July 7, 2020 /EINPresswire.com/ -- Leading regenerative veterinary medicine company, VetStem Biopharma, has reached a new stem cell treatment milestone. The San Diego based company has processed nearly 14,000 patient samples resulting in over 30,000 stem cell treatments for animals across the United States and Canada.As the fi

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[2020-06-30] New Stem Cell-Based Application for BeyondSpring’s Plinabulin Presented at ISSCR Annual Meeting

简介: Data Presented Shows Plinabulin Mobilizes Bone Marrow CD34+ Progenitor Cells through a Mechanism of Action Independent from G-CSFs and CXCR4 /EIN News/ -- NEW YORK, June 30, 2020 (GLOBE NEWSWIRE) -- BeyondSpring Inc. (the “Company” or “BeyondSpring”) (NASDAQ: BYSI), a global biopharmaceutical company focused on the development of innovative immuno-oncology cancer therapies, today announced that the Company presented clinical data on BeyondSpring’s first-in-class, late-stage asset, Plinabuli

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[2020-06-27] UAE stemcell treatment for covid-19 reaches over 2000 patients

简介: ABU DHABI. KAZINFORM - The Abu Dhabi Stem Cell Centre, ADSCC, has now treated more than 2,000 patients suffering from COVID-19, with 1200 already fully recovered from the effects of the virus, WAM reports. ADSCC announced today that it had succeeded in ramping up the number of treatments from the 73 in the initial clinical trial. The large increase was as a result of a major effort by staff at the centre to treat as many people as possible following the UAE Government’s decision to make it avail

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[2020-06-24] R3 Stem Cell Training Courses Now Enrolling for August 2020 in San Diego and Nashville

简介: The R3 Comprehensive Stem Cell Training Courses have been scheduled for August 2020 for both San Diego and Nashville. The two day courses offer providers a hands on approach to learning techniques for stem cell procedures with real patientsSAN DIEGO (PRWEB) June 24, 2020The R3 Comprehensive Stem Cell Training Courses have been scheduled for August 2020 for both San Diego and Nashville. The two day courses offer providers a hands on approach to learning techniques for stem cell procedures with re

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[2020-06-16] 广州生物院在动物模型上实现诱导多能干细胞来源CAR-T细胞抗肿瘤

简介: 6月15日，中国科学院广州生物医药与健康研究院王金勇课题组在《细胞与分子免疫》（Cellular & Molecular Immunology）杂志在线发表了题为Pluripotent stem cell-derived CD19-CAR iT cells effectively eradicate B-cell lymphoma in vivo的论文。基于课题组前期开发的“体外获得T细胞种子，体内发育成熟”两步法再生T细胞技术，该研究进一步结合嵌合抗原受体T细胞免疫疗法（CAR-T）抗肿瘤原理，通过诱导多能干细胞获得抗肿瘤特异性的CAR-T细胞，在动物模型上成功实现体内清除肿瘤。CAR-T在治疗血液肿瘤、黑色素瘤等肿瘤的治疗效果已被临床验证。目前CAR-T细胞的主要来源是患者自体的外周血T细胞，受到患者自身免疫状态的局限，该技术的应用普及度受到限制。因此，制备新型来源CAR-T细胞仍然是亟待解决的问题。众所周知，纯体外诱导获得的表型T细胞移植后体内活性很差，根源就在于体外无法成功模拟胸腺微环境。研究人员采用前期研究建立的两步法再生T细胞技术，结合CAR-T技术原理，获得了针对

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[2020-06-15] Texas Heart Institute and 7 Hills Pharma receive $1.9 million to improve stem cell transplants

简介: The Texas Heart Institute and 7 Hills Pharma (7 Hills) received a $1.9 million, Phase II STTR (R42) grant from the National Heart Lung Blood Institute to advance further their lead product 7HP349, a novel integrin activator, to define the optimal dosing schedule for cord blood transplant along with a focus on development and production of a formulation that meets safety standards for filing an IND application with the FDA.The growing use of umbilical cord blood cells for bone marrow transplantat

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[2020-06-15] 昆明动物所发现乳腺癌干细胞的调控新机制

简介: 　三阴性乳腺癌 (TNBC) 缺少雌激素受体 (ER) 、孕激素受体 (PR) 和人表皮生长因子受体2（HER2）的表达，是恶性程度高、易转移、高复发和预后差的一类乳腺癌。由于缺乏有效的治疗靶点，化疗是TNBC主要的治疗方式之一，然而化疗药物能够杀死正在分裂的肿瘤细胞，却不能有效作用于肿瘤干细胞，从而导致肿瘤干细胞的富集，进而产生TNBC的耐药性。因此由肿瘤干细胞介导的耐药性是TNBC治疗的研究难点之一。中国科学院昆明动物研究所焦保卫团队与陈策实团队合作，结合TNBC单细胞测序数据，鉴定了一个在乳腺癌干细胞（BCSC）中高表达的基因-SGCE。表型分析发现SGCE对于乳腺癌干细胞的自我更新不可或缺。在机制探讨上，发现SGCE与E3泛素连接酶c-Cbl相互结合，SGCE缺失促进c-Cbl释放出来而泛素化其底物蛋白EGFR，从而使得EGFR进入网格蛋白介导和巨胞饮途径的内化，内化的EGFR进而进入溶酶体降解。EGFR的降解导致其下游通路被阻断并最终抑制BCSC自我更新和胞外基质ECM的累积。SGCE在BCSC中高表达时，SGCE与c-Cbl相互结合，EGFR能够正常激活其下游信号通路PI3

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