干细胞领域知识发现平台

[2020-03-20] 科学家发现小鼠胰岛成体干细胞身份并建立胰岛类器官长期扩增培养体系

简介: 北京时间3月19日，中国科学院分子细胞科学卓越创新中心（生物化学与细胞生物学研究所）曾艺研究组的文章“Long-term expansion of pancreatic islet organoids from resident Procr+ progenitors”在国际学术期刊《细胞》（Cell）上发表。该研究发现并鉴定了小鼠胰岛中的干细胞类群，基于这些干细胞，建立了小鼠胰岛类器官体外长期扩增的培养体系。糖尿病是由遗传因素和环境因素长期共同作用导致的一种慢性、全身性代谢疾病。全球有4.3亿的糖尿病患者，其中1/4在中国。胰岛β细胞功能失常导致的胰岛素分泌不足是1型糖尿病和2型糖尿病的共同特征之一，许多患者需要终生使用胰岛素进行治疗。近年来，胰岛移植作为新兴的糖尿病治疗方法取得了一定的成功。但供体胰岛的严重不足极大限制了这种方法的普及。如何打破供体的局限，获得可用于移植的功能性胰岛β细胞，一直是糖尿病治疗领域的巨大挑战。如何源源不断地获得可用于移植的胰岛β细胞？一种思路是通过胚胎干细胞 (ES/iPS) 定向诱导分化来获取功能性胰岛细胞，这类研究在国际上已经取得了

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[2020-03-20] Recombinant Cell Culture Supplements Receive a Boost from Stem Cell Research Ventures; Demand for Novel Vaccines to Act as a Growth Lever, Says PMR

简介: Increasing R&D activities in stem cell space are fueling the growth of the recombinant cell culture supplements market. The growing demand for novel vaccines is accelerating sales of recombinant cell culture supplements, positively influencing market performance./EIN News/ -- New York, United States, March 20, 2020 (GLOBE NEWSWIRE) -- The global recombinant cell culture supplements market, valued at US$ 320 Mn by the end of 2018, will grow at a steady rate from 2029-2029. The market players

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[2020-03-19] PA Green Wellness is Now Offering Mesenchymal Stem Cell Treatments to Support Lung Health During COVID-19

简介: KING OF PRUSSIA, PENNSYLVANIA, UNITED STATES, March 19, 2020 /EINPresswire.com/ -- In the wake of a global health crisis, PA Green Wellness has adapted its signature wellness injection to aid in lung health, restoration of damage and an overall reduction in inflammatory responses.The medical director of PA Green Wellness, Dr. Richard Magill, MD states; “Mesenchymal Stem Cells (MSCs), unsurprisingly have been a focal point during this pandemic due to their ability to reduce inflammation and assis

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[2020-03-17] 科技部生物中心：干细胞治疗新冠肺炎患者初步显示有效

简介: 科技部生物中心主任张新民在17日的国务院联防联控机制新闻发布会上说，新冠肺炎疫情发生以来，科研攻关组第一时间启动了干细胞治疗新冠肺炎临床研究应急攻关项目。结果初步显示，干细胞治疗新冠肺炎患者安全、有效，能够使重症、危重症患者呼吸困难较快得到缓解或者停止加重，在临床表现、呼吸功能、影像检查等方面均实现好转。另外，干细胞对于肺纤维化进程的阻断以及促进肺部损伤修复的作用，显示其对于防止肺纤维化、改善患者远期预后具有一定的优势。

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[2020-03-13] 广州生物院揭示神经干细胞分化新机制

简介: 　3月10日，中国科学院广州生物医药与健康研究院、广州再生医学与健康广东省实验室郑辉课题组在国际学术期刊FASEB Journal 在线发表了题为Naloxone Regulates the Differentiation of Neural Stem Cells via a Receptor-independent Pathway 的研究论文。该成果揭示了非阿片受体途径在阿片受体拮抗剂纳洛酮（naloxone）调控神经干细胞分化中的作用。神经干细胞（NSCs）分化是指神经干细胞通过不对称分裂产生神经元、星形胶质和少突胶质等细胞的过程。阿片类药作为临床常用的镇痛药物，极大地缓解了病人的痛苦，然而阿片类药物的耐受和成瘾过程也明显地影响了学习记忆能力。多项研究表明，阿片类药物可以调控NSCs分化方向，影响机体成体神经发生及其学习和记忆能力，那么阿片类药物对NSCs分化的影响是否完全依赖于阿片受体呢？研究团队以阿片受体拮抗剂纳洛酮为代表研究了阿片类药物调控NSCs分化的机制。发现在阿片受体及其内源配体表达极低的NSCs中，纳洛酮通过进入细胞内促进NSCs向神经元分化，而丧失细胞膜穿透能力的纳

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[2020-03-11] 全球第二位被治愈的艾滋病患者：“伦敦病人”

简介: 2019 年 3 月，Nature 杂志发表了一篇重磅论文，报告了一名伦敦男子在接受 * 干细胞移植后其艾滋病可能已被治愈。这也是继“柏林病人”之后，全球第二位成功治愈艾滋病的患者。2020 年 3 月 10 日，《柳叶刀》子刊 The Lancet HIV 在线发表了伦敦病人的详细治疗过程和身份信息。该结果的发表也意味着，经过共 30 个月的观察，这位 “伦敦病人” 的血液、淋巴组织、肠道组织中均未发现病毒，其艾滋病已被治愈。同时，在最新论文中，这位 “伦敦病人” 的身份也被公开。现年 40 岁的 Adam Castillejo 在 2003 年诊断出艾滋病，他成为继 “柏林病人” 后，又一位被治愈的艾滋病患者。不过研究者也表示，这两位患者接受移植的最初目的，是为了治疗癌症，目前用该手段治疗艾滋病还不具备普适性、存在较大风险。艾滋病治疗史唯二的奇迹在此之前，世界上首个被成功治愈的艾滋病患者，也是之前唯一一个被成功治愈的艾滋病患者，就是广为人知的 “柏林病人”，名叫 Timothy Ray Brown。2007 年，居住在柏林的美国艾滋病人 Timothy Brown 确诊自己得了急性

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[2020-03-07] Once experimental, Ste-Justine's Hospital prepares for 1,000th stem cell transplant

简介: By their own admission, Jessica and Joel Makuma don’t always get along. Joel likes to dance in his big sister’s bedroom, which led her to kick him out (“he had it coming,” she said with a smile). And, he recalls ruefully, “one time she told me she hates me.”But the brother and sister are about to put aside these spats of sibling rivalry, as they become part of a milestone for Ste-Justine Hospital: they’re going to become the 1,000th stem cell transplant the hospital has performed.Jessica, 12, su

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[2020-03-05] China uses stem cell therapy to treat severe COVID-19 cases

简介: Chinese researchers are studying the use of stem cell technology in the treatment of people critically ill with the novel coronavirus disease (COVID-19), according to the Science and Technology Daily.Four COVID-19 patients who received stem cell treatment while in a serious condition have been discharged from hospital after recovery, and the clinical trial of the therapy will be further expanded, Vice Minister of Science and Technology Xu Nanping, was quoted by the paper as saying.Stem cells can

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[2020-03-05] Prohibition of public funding for abortion, cloning, stem cell research heard in Senate

简介: A bill to permanently prohibit tax-payer funding for abortion, cloning and other prohibited human research was heard in the Senate Health and Pensions Committee on Wednesday. Senate Bill 917, proposed by Sen. Bob Onder, R-Lake St. Louis, mirrors language that has passed in every budget since 2017, Onder said during the hearing, and would act as "Missouri's Hyde Amendment," which blocks federal funds from being used to pay for abortion outside of certain exceptions."This would protect Missou

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[2020-03-04] Stem Cell Therapy for Coronavirus Infection

简介: GOLDEN, CO,March 3 2020 /Vitro Diagnostics, Inc. (OTCPK:VODG), dba Vitro Biopharma reports on a potential therapy of Coronavirus (COVID-19) infections by stem cell transplant. While this therapy is not a method to eradicate or cure Coronavirus, there is evidence to support the concept that infected patients may be more likely to combat and survive infection. First, stem cells resist viral attack by the expression of certain genes known as interferon gamma stimulated genes (ISGs). These are expre

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